N. meningitidis and cell cycle alteration
The host cell cycle is involved in many processes- such as immune responses, maintenance of epithelial or endothelial barrier function and cellular differentiation, processes which affect bacterial growth and colonization. Bacteria may also target the host cell cycle and a growing number of bacteria have been described that produce cyclomodulins (e.g. toxins) that actively interfere with the host cell cycle. The eukaryotic cell cycle consists of four phases: G1, S, G2, and M. Control and progression through these phases are controlled by positive regulators, including the cyclins and their partner molecules, cyclin-dependent kinases (CDKs). Four different classes of cyclins have been defined on the basis of the stage of the cell cycle in which they bind and activate CDKs. These four classes are G1-cyclins (CyclinD1, D2 and D3), G1/S-cyclins, S-cyclins, and M-cyclins.
Transcriptome profiling of endothelial cells infected with meningococci demonstrated that this pathogen is also capable to interfere with the cell cycle.
In this new project we seek to analyze the impact of N. meningitidis on cell cycle alteration in infected endothelial and epithelia cells.
This project currently receives funding from DFG.
New funding - 2014-2016
Untersuchungen zum Einfluß der Meningokokkeninfektion auf die Aktivierung von Rezeptor-Tyrosinkinasen sowie auf den Zellzyklus