The German National Reference Centre for Meningococci and Haemophilus influenzae (NRZMHi) is assigned by the Robert Koch Institute (RKI) with the performance of laboratory based surveillance of invasive meningococcal disease (IMD). In 2018, 361 samples from 320 individuals were analyzed. The NRZMHi confirmed Neisseria meningitidis in 264 patients, in 235 of them from primarily sterile compartments (latter figure corresponds to the number of cases with invasive disease). In 32 patients (13.6% out of 235) detection of meningococci was carried out using molecular techniques only. During the same period 295 cases of IMD were notified to the RKI (data as of 16.01.2019, SurvStat@RKI). Given that all processed cases of IMD were notified retrospectively, one can assume an 80% coverage of IMD by NRZMHi (82% in 2017).
There were only minor changes of the incidence of IMD in Germany: 0.34/100,000 in 2017 vs. 0.36/100,000 in 2018 (data as of 16.01.2019, SurvStat@RKI).
The number of serogroup Y cases analysed at the NRZMHi continued to increase in 2019. Furthermore, an increase of serogroup B cases was observed. There were less serogroup C and W cases than in the previous year.
Please consider: Since 2019, whole-genome-sequencing is applied to all invasive meningococcal isolates at the NRZMHi. The analysis of the sequence data is not finished yet. Therefore, the previous depiction of meningococcal finetypes based on PorA and FetA sequencing is no longer available. In the future, genome sequencing will provide high-resolution insights into molecular epidemiological trends.
The coloured symbols represent IMD cases with the respective serogroups. Serogroup C dominated in Baden-Wuerttemberg and Y in North Rhine-Westphalia.
All maps were generated with EpiScanGIS.
In 2018, the majority of IMD cases irrespective of the serogroup occurred in patients aged 20 years or above.
For four invasive cases, the serogroup could not be determined (NG).
The proportions of penicillin intermediate susceptible isolates increase from 24,0% (2018) to 30,6% (2019), whereas the proportions of penicillin resistant isolates remained almost stable (5,1% vs. 5,9%).
The above data were generated with federal funds (RKI). Scientific use is prohibited without prior written consent by NRZMHi or RKI. Commercial use is strictly prohibited. Inclusion of figures or tables in talks or oral presentations is not allowed.
© NRZMHi 2020