New paper in mBio05/04/2020
In a global collaboration, researchers from the IHM could trace the evolutionary history and global expansion of Candida auris
Over the past years, C. auris has emerged in health care settings as a multidrug-resistant organism worldwide. It can spread via nosocomial transmission and cause outbreaks of invasive infections. The pathogenic yeast carries high rates of drug resistance with some isolates exhibiting resistance to all major classes of antifungals. The research group of Professor Oliver Kurzai was part of an international team, which assessed the genome evolution of isolates of C. auris from 19 countries. Based on population genomic analysis, four predominant clades and their discrete phylogeographic population structure could be defined. The researchers could also give an estimated timing of the expansion of each C. auris clade and of fluconazole resistance, revealing that the different clades evolved in relatively short time periods. Comparison of genome data and sensitivity measurements revealed how antifungal resistance mechanisms vary across the population. Molecular epidemiology studies are critical for a sustained and robust public health response.
Chow NA, Muñoz JF, Gade L, Berkow EL, Li X, Welsh RM, Forsberg K, Lockhart SR, Adam R, Alanio A, Alastruey-Izquierdo A, Althawadi S, Araúz AB, Ben-Ami R, Bharat A, Calvo B, Desnos-Ollivier M, Escandón P, Gardam D, Gunturu R, Heath CH, Kurzai O, Martin R, Litvintseva AP, Cuomo CA. 2020. Tracing the evolutionary history and global expansion of Candida auris using population genomic analyses. mBio 11:e03364-19.https://doi.org/10.1128/mBio.03364-19.