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Intern
    Institut für Hygiene und Mikrobiologie

    New Paper in Front. Cell Dev. Biol.

    21.10.2019


    In a current collaboration project with the group of Prof. M Sauer (http://www.super-resolution.biozentrum.uni-wuerzburg.de/startseite/) Jan Schlegel (AG Markus Sauer) and Simon Peters (AG Schubert-Unkmeir) investigated the mobility of CD147 upon N. meningitidis infection by single-molecule tracking experiments. They analysed the role of the two sphingolipids GM1 and Gb3 during infection with N. meningitidis using fluorescently labeled CTxB and STxB subunits, respectively. Super-resolution microscopy by structured illumination microscopy (SIM) and direct stochastic optical reconstruction microscopy (dSTORM) showed GM1 accumulation around meningococci highlighting their significant importance for bacterial invasion.

    Reference:

    Schlegel J, Peters S, Doose S, Schubert-Unkmeir A, Sauer M (2019) Super-resolution microscopy reveals local accumulation of plasma membrane gangliosides at Neisseria meningitidis invasion sites. Front Cell Dev Biol. 2019 Sept 7, 194.

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