Institut für Hygiene und Mikrobiologie

    IHM researchers quantify the risk of invasive meningococcal infections


    Manuel Krone, Thiên-Trí Lâm, Heike Claus, Ulrich Vogel, Recurrent invasive meningococcal infections – quantifying the risk, Germany, 2002 to 2018. Eurosurveillance 2020;25(25):pii=1900565. https://doi.org/10.2807/1560-7917.ES.2020.25.25.1900565

    Bild: Serogroup distribution of single and recurrent invasive meningococcal infections, Germany, 2002 to 2018 (n = 5,869), Source: Krone et al., Eurosurveillance 2020;25(25)

    While recurrent meningococcal infections have been described in literature since the 1940s, the incidence has been unknown before. The team of the national reference laboratory for meningococci and Haemophilus influenzae has now analyzed data from 5 854 patients over 17 years, created a Markov model and thereby calculated for the first time the incidence of recurrent invasive meningococcal infections.

    Data showed that survivors of invasive meningococcal infections are at least at a 50-fold risk of another episode compared to the general population. These data argue for vaccination of these survivors against all vaccine preventable meningoccal serogroups (A, B, C, W, Y) to prevent further potentially lethal episodes of meningococcal infections.

    32-yr old Manuel Krone is the corresponding author of the study. He is currently completing his training as a medical microbiologist.