Intern
    Institut für Hygiene und Mikrobiologie

    AG Brehm

    Welcome to the Brehm lab.

     

    Our work aims at elucidating molecular host-parasite interactions in cestode infections, cestode genetics/genomics and developmental biology, immune evasion by flatworm parasites, and the development of novel anti-infectives against flatworm parasite diseases.  As a model system we are focusing on the fox-tapeworm Echinococcus multilocularis, the causative agent of the lethal disease alveolar echinococcosis.

    To learn more about E. multilocularis and it’s life cycle, read here.

    How we approach the parasite? Please read the following pages:

    in vitro cultivation
    host-parasite interaction
    genomics/proteomics
    drug development

    Some of our recent publications:

     

    Brehm, K., Koziol, U. (2017) Echinococcus – Host interactions at cellular and molecular levels. Advances in Parasitology 95: 147-212.

    Koziol, U., Jarero, F., Olson, P.D., Brehm, K. (2016) Comparative analysis of Wnt expression identifies a highly conserved developmental transition in flatworms. BMC Biology 14:10.

    Koziol, U., Radio, S., Smircich, P., Zarowiecki, M., Fernández, C., Brehm, K. (2015) A novel terminal-repeat retrotransposon in miniature (TRIM) is massively expressed in Echinococcus multilocularis stem cells. Genome Biology and Evolution 7: 2136-2153.

    Koziol, U., Brehm, K. (2015) Recent advances in Echinococcus genomics and stem cell research. Vet. Parasitol. 213: 92-102.

    Schubert, A., Koziol, U., Cailliau, K., Vanderstraete, M., Dissous, C., Brehm, K. (2014) Targeting Echinococcus multilocularis stem cells by inhibition of the Polo-like kinase EmPlk1.
    PLoS Negl. Trop. Dis. 6: e2870.

    Koziol, U., Rauschendorfer, T., Zanon-Rodriguez, L., Krohne, G. and Brehm, K. (2014) The unique stem cell system of the immortal larva of the human parasite Echinococcus multilocularis.
    EvoDevo 5: 10.

    Nono, J.K., Lutz, M.B., and Brehm, K. (2014) EmTIP, a T-cell immunomodulatory protein secreted by the tapeworm Echinococcus multilocularis is important for early metacestode development.
    PLoS Negl. Trop. Dis. 8: e2632.

    Hemer, S., Konrad, C., Spiliotis, Koziol, U., M., Schaack, D., Förster, S., Gelmedin, V., Stadelmann, B., Dandekar, T., Hemphill, A., Brehm, K. (2014) Host insulin stimulates Echinococcus multilocularis insulin signalling pathways and larval development.
    BMC Biol. 12: 5.

    Koziol, U., Krohne, G., Brehm, K. (2013) Anatomy and development of the larval nervous system in Echinococcus multilocularis.
    Front. Zool. 10: 24.

    Tsai, I.J. et al. (2013) The genomes of four tapeworm species reveal adaptations to parasitism.
    Nature 496: 57-63

    Kontakt

    Institut für Hygiene und Mikrobiologie
    Josef-Schneider-Straße 2
    97080 Würzburg

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